Polynucleotide (PDRN) injections are one of the most advanced skin regeneration treatments available. Administered by GMC-registered doctors, they stimulate your skin's own repair mechanisms for deep, lasting improvement.
Polynucleotides (also known as PDRN) are injectable skin boosters derived from highly purified salmon DNA. They work by stimulating fibroblasts — the cells responsible for producing collagen and elastin — triggering genuine skin regeneration from within.
We use Plinest One and the premium Plinest range, offering treatment for the under eyes, full face, neck and scalp. Results improve progressively over the course of treatment.
| Treatment time | 30–45 minutes |
| Course recommended | 3 sessions, 3–4 weeks apart |
| Maintenance | Every 9–12 months |
| Downtime | Minimal |
| Administered by | GMC-registered doctor |
| Starting from | £160 |
Client consent obtained. Individual results may vary.
All prices include your free consultation. Prices may vary depending on the product used and individual treatment plans — full details discussed at consultation.
Plinest One
Plinest (Premium)
Recommended course of 3 sessions, every 3–4 weeks. Maintenance every 9–12 months.
In the UK, many aesthetic treatments are currently unregulated — meaning anyone can administer them without medical training. At Revitalise Aesthetics, every treatment is carried out by a GMC-registered doctor.
Plinest One is our standard polynucleotide treatment. Plinest is the premium formulation with a higher concentration, ideal for those wanting deeper regeneration. Your doctor will recommend the best option at your consultation.
Polynucleotides work progressively. Some clients notice improvement after the first session, with best results visible 4–6 weeks after completing the recommended course of 3.
Yes — the under eye is one of the most popular areas for polynucleotides. It helps with hollowing, dark circles and crepey skin that can be difficult to address with other treatments.
They are similar in that both are injectable hydration treatments, but polynucleotides go further — they actively stimulate cellular regeneration rather than just adding moisture.
Results from a full course typically last 9–12 months, after which a maintenance session is recommended.